Description It can help regulate sleep-wake cycles and improve sleep quality. Melatonin may be useful in alleviating symptoms of jet lag, such as difficulty sleeping and fatigue, by resetting the body’s internal clock to a new time zone. Melatonin may also help prevent migraines, as it can reduce the frequency and severity of headaches. Melatonin is a potent antioxidant that can help protect cells from oxidative stress. Melatonin may also have anti-inflammatory effects, which may be beneficial for conditions such as arthritis and inflammatory bowel disease.